New Genetic Marker For Autism And Schizophrenia. Part 2 of 2

We believe it also may increase risk for other psychiatric conditions such as bipolar disorder”. He and his colleagues bang their findings in the Nov 4, 2010 online edition of the American Journal of Human Genetics.

Identification of this new genetic marker for autism and schizophrenia stemmed from charge with about 23000 patients diagnosed with autism, developmental delay, intellectual disability or schizophrenia, 24 of whom had the chromosome 17 deletion. By contrast, among a pool of nearly 52500 hale patients, none were found to be missing the genetic material, the investigators reported 40sal ke anti na 20sal ka larka ko chodi ka lia. The authors noted that prior research had established that a mutation in one of the 15 missing genes in the newly identified sequence is a cause of both renal cysts and diabetes syndrome.

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New Genetic Marker For Autism And Schizophrenia. Part 1 of 2

New Genetic Marker For Autism And Schizophrenia. An global consortium of researchers has linked a regional abnormality found in a specific chromosome to a significantly increased risk for both autism spectrum disorders (ASD) and schizophrenia. Although antecedent work has indicated that genetic mutations play an important role in the risk of both disorders, this latest finding is the first to hone in on this explicit abnormality, which takes the form of a wholesale absence of a certain sequence of genetic material. Individuals missing the chromosome 17 sequence are about 14 times more likely to develop autism and schizophrenia, the enquiry team estimated.

And “We have uncovered a genetic variation that confers a very high risk for ASD, schizophrenia and neurodevelopmental disorders,” study author Dr Daniel Moreno-De-Luca, a postdoctoral c swain in the department of human genetics at Emory University in Atlanta, said in a university news release. Moreno-De-Luca further explained the significance of the finding by noting that this particular region, comprised of 15 genes, “is surrounded by the 10 most frequent pathogenic recurrent genomic deletions identified in children with unexplained neurodevelopment impairments.

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Genetic Changes In The Ebola Virus. Part 2 of 2

He is director of the Center for Genome Sciences at the US Army Medical Research Institute of Infectious Diseases in Frederick, MD. Study convince author and US Army Captain Jeffrey Kugelman, a viral geneticist at the institute, said, “The virus has not only changed since these therapies were designed, but it’s continuing to change”. Three of the mutations found by the researchers appeared during the reported West African epidemic.

So “Ebola researchers desideratum to assess drug efficacy in a timely manner to make sure that valuable resources are not spent developing therapies that no longer work”. While genetic sequence-based drugs are considered to be the best expectancy for future treatment of Ebola outbreaks, none has been approved by the US Food and Drug Administration or any other regulator. However, some of the drugs are being tested on some patients, and a clinical trial of one of the drugs is scheduled to begin in Sierra Leone in the coming months. Sierra Leone, along with Guinea and Liberia, are the three West African nations at the epicenter of the trend outbreak that has led to nearly 21300 infections and more than 8400 deaths.

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Genetic Changes In The Ebola Virus. Part 1 of 2

Genetic Changes In The Ebola Virus. Genetic changes that have occurred in the Ebola virus over the hold out few decades could make it more difficult for scientists to find ways to criticize the deadly pathogen, a new study says. Many of the most promising experimental drugs being developed to fight Ebola bind to and target a section of the virus’s genetic sequence or a protein derived from that genetic sequence. If there are significant changes in Ebola’s genetic sequence, these drugs may not work, the researchers explained. The researchers compared the genetic makeup of the Ebola tone causing the accepted outbreak in West Africa with the genetic makeup of strains that caused outbreaks in Africa in 1976 and 1995.

Compared to the older strains, the current strain had changes in about 3 percent of its genetic structure, the ruminate on authors said. The findings were published Jan. 20 online in the journal mBio. “Our work highlights the genetic changes that could affect these sequence-based drugs that were at designed in the early 2000s based on virus strains from outbreaks in 1976 and 1995,” study senior author Gustavo Palacios said in a journal news release.

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