Tag Archives: researchers

People Often Die In Their Sleep. Part 2 of 3

People Often Die In Their Sleep – Part 2 of 3

The CPAP system consists of a motor that pushes air through a tube connected to a mask that fits over the patient’s opening and nose. The device keeps the airway from closing, and thus allows continuous sleep. Sleep apnea is a common disorder. The pauses in breathing that patients adventure can last from a few seconds to minutes and they can occur 30 times or more an hour.


As a result, sleep quality is poor, making sleep apnea a leading cause of excessive daytime sleepiness, according to the US National Heart, Lung, and Blood Institute. Dr Gregg Fonarow, a spokesman for the American Heart Association and professor of cardiology at the University of California, Los Angeles, agrees that most patients with hard-to-control pongy blood power also suffer from sleep apnea. “Close to three out of four patients with resistant high blood pressure have been found to have obstructive sleep apnea, and this sleep apnea may grant to the difficulty to control the blood pressure in these patients.

Although this study showed a benefit from CPAP in controlling blood pressure, questions remain about the treatment’s overall effectiveness. “Whether these improvements in blood pressure can be continuous in the long term and will translate to improved health outcomes will require additional studies. According to the chief medical liaison for Philips Respironics, Dr Teofilo Lee-Chiong, the CPAP monogram allows the patient to sleep, and thus lets the blood pressure drop normally as it would at night.

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People Often Die In Their Sleep. Part 1 of 3

People Often Die In Their Sleep – Part 1 of 3

People Often Die In Their Sleep. People with catch apnea and hard-to-control high blood pressure may see their blood pressure drop if they treat the forty winks disorder, Spanish researchers report. Continuous positive airway pressure (CPAP) is the standard treatment for sleep apnea, a condition characterized by disrupted breathing during sleep. The take disorder has been linked to high blood pressure. Patients in this study were taking three or more drugs to lower their blood pressure, in addition to having sleep apnea.

Participants who used the CPAP device for 12 weeks reduced their diastolic blood arm (the bottom number in a blood pressure reading) and improved their overall nighttime blood pressure, the researchers found. “The prevalence of sleep apnea in patients with unruly high blood pressure is very high,” said lead researcher Dr Miguel-Angel Martinez-Garcia, from the Polytechnic University Hospital in Valencia. “This sleep apnea care increases the probability of recovering the normal nocturnal blood pressure pattern.

Patients with resistant high blood pressure should undergo a sleep study to rule out obstructive sleep apnea, Martinez-Garcia said. “If the stoical has sleep apnea, he should be treated with CPAP and undergo blood pressure monitoring”. The report, published in the Dec 11, 2013 issue of the Journal of the American Medical Association, was partly funded by Philips-Respironics, maker of the CPAP combination used in the study.

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Excess Weight Is Not The Verdict. Part 3 of 3

Excess Weight Is Not The Verdict – Part 3 of 3

And “There was some superiority loss, but it was transient”. Now a key question is, what is the right setting for the deep brain stimulation to foster lasting weight loss? Whiting said his team is continuing to follow these three patients to try to figure that out – and to keep monitoring safety. Although deep brain stimulation is considered a largely safe therapy for the right patients, it is a major undertaking that requires two surgeries – one to implant electrodes in the brain and another to place the neurostimulator.

The potential risks include infection, a blood clot or bleeding in the brain, or an allergic effect to the DBS parts. If deep brain stimulation ever does become an option for managing severe obesity he would expect it only to be used when all else fails. “This would categorically be a last resort.

So “At first, it would absolutely be a last-ditch option,” neurosurgeon Halpern said. But it’s also possible that deep brain stimulation could become an add-on therapy, second-hand after gastric bypass for some patients whose weight does not fall – or even an alternative in certain cases where bypass surgery is too risky. Medtronic provided the deep brain stimulation hardware for the study and funded the work can klonopin increase sex drive. One of Whiting’s co-researchers is employed by the company.

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Excess Weight Is Not The Verdict. Part 2 of 3

Excess Weight Is Not The Verdict – Part 2 of 3

Research in animals has shown that electrical stimulation of a special area of the brain – the lateral hypothalamic area – can spur weight loss even if calorie intake stays the same. The new writing-room marks the first time that deep brain stimulation has been tried in that brain region. And it’s an important first step to show that not only could these three severely obese people get through the surgery, but they also seemed to have no fooling effects from the brain stimulation, said Dr Casey Halpern, a neurosurgeon at the University of Pennsylvania who was not involved in the research.


And “That shows us this is a therapy that should be studied further in a larger trial,” said Halpern, who has done subhuman research exploring the idea of using deep brain stimulation for obesity. “Obesity is a major problem and current therapies, even gastric bypass surgery, don’t always work. There is a medical have occasion for for new therapies”.

The three patients in Whiting’s study were examples of that medical need. All were severely obese and had failed to shed weight after gastric bypass surgery – the up to date last-ditch treatment option. During the study period, the patients did have some side effects from deep brain stimulation – nausea, anxiety and feeling “too peppery or flushed” – but they were short-lived, the researchers said.

And there was some evidence that the brain stimulation was having effects. In lab tests, Whiting’s team found that the deep brain stimulation seemed to impel short-lived spikes in resting metabolism. Then, after the deep brain stimulation was programmed to the settings that seemed to boost metabolism, two patients shed some pounds – 12 percent to 16 percent of what they weighed before the DBS settings were “optimized”.

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Excess Weight Is Not The Verdict. Part 1 of 3

Excess Weight Is Not The Verdict – Part 1 of 3

Excess Weight Is Not The Verdict. For the anything else time, researchers have shown that implanting electrodes in the brain’s “feeding center” can be safely done – in a bid to age a new treatment option for severely obese people who fail to shed pounds even after weight-loss surgery. In a preliminary study with three patients, researchers in June 2013 found that they could safely use the therapy, known as heavily brain stimulation (DBS). Over almost three years, none of the patients had any serious side effects, and two even lost some weight – but it was temporary. “The maiden thing we needed to do was to see if this is safe,” said lead researcher Dr Donald Whiting, vice chairman of neurosurgery at Allegheny General Hospital in Pittsburgh.

And “We’re at the point now where it looks be fond of it is”. The study, reported in the Journal of Neurosurgery and at a meeting this week of the International Neuromodulation Society in Berlin, Germany, was not meant to test effectiveness. So the big remaining uncertainty is, can deep brain stimulation actually promote lasting weight loss?

“Nobody should get the idea that this has been shown to be effective. This is not something you can go ask your doctor about”. Right now, deep intellectual stimulation is sometimes used for tough-to-treat cases of Parkinson’s disease, a movement disorder that causes tremors, stiff muscles, and balance and coordination problems. A surgeon implants electrodes into fixed movement-related areas of the brain, then attaches those electrodes to a neurostimulator placed under the skin near the collarbone.

The neurostimulator continually sends tiny electrical pulses to the brain, which in turn interferes with the aberrant activity that causes tremors and other symptoms. What does that have to do with obesity? In theory deep brain stimulation might be able to “override” brain signaling involved in eating, metabolism or feelings of fullness.

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The Biggest Stroke Risk Factors. Part 3 of 3

The Biggest Stroke Risk Factors – Part 3 of 3

So “Who knows what combination of factors are at play in any particular person?” Katzan concluded. People who imbibe should consider cutting back their intake if they are having two or more drinks a daytime on average, Katzan and Kadlecova said. “It is okay to drink in moderation. The ideal is consuming less than two drinks per day for men, and for non-pregnant women the paramount should be no more than one drink per day” womens.

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The Biggest Stroke Risk Factors. Part 2 of 3

The Biggest Stroke Risk Factors – Part 2 of 3

By comparison, light drinkers’ or nondrinkers’ stroke risk increased gradually with age. Among identical twins, siblings who had a stroke drank more than their siblings who hadn’t had a stroke, suggesting that midlife drinking raises work risks regardless of genetics and early lifestyle, the researchers said. Midlife heavy drinkers – those in their 50s and 60s – were odds-on to have a stroke five years earlier in life, irrespective of genetic and lifestyle factors, the study found.


The findings are consistent with national guidelines that recommend a top of two drinks a day for men and one for women, said Dr Irene Katzan, a staff neurologist and director of the Center for Outcomes Research and Evaluation at the Cleveland Clinic. That translates to a quotidian maximum of about 8 ounces of wine for a man and 4 ounces for a woman. “It’s a nice study that corroborates what we’ve known about alcohol and stroke, and it corroborates the recommendations that are in the nationwide guidelines”.

It’s not clear exactly how alcohol affects stroke risk, but some theories center on the fact that alcohol thins your blood. This could increase your risk of hemorrhagic stroke, in which a blood utensil breaks inside the brain. “The more you drink, the more risk you have of bleeding in the brain. At the same time, it’s also well-known that alcohol contributes to high blood pressure and can increase the chances of atrial fibrillation, two other health-related endanger factors for stroke.

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